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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
07/06/2022 |
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Actualizado : |
30/11/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
MACHADO, M.; CASTRO, M.B.; WILSON, T. M.; GONÇALVES , A. A. B.; PORTIANSKY, E.; RIET-CORREA, F.; BARROS, S. S. |
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Afiliación : |
MIZAEL MACHADO DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MÁRCIO B. CASTRO, University of Brasilia, Brasília, Brazil; TAIS M. WILSON, University of Brasilia, Brasília, Brazil; ALEXANDRA A. B. GONÇALVES, University of Brasilia, Brasília, Brazil; ENRIQUE L. PORTIANSKY, National University of La Plata, La Plata, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Federal University of Bahia, Salvador, Brazil; SEVERO S. BARROS, Federal University of Santa Maria, Rio Grande do Sul, Brazil. |
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Título : |
Poisoning by Nierembergia veitchii: Effects on vascular smooth muscle cells in the pathogenesis of enzootic calcinosis. |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
Veterinary Pathology, 2022, Volume 59, Issue 5, pages 814-823. doi: https://doi.org/10.1177/03009858221098430 |
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ISSN : |
0300-9858 |
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DOI : |
10.1177/03009858221098430 |
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Idioma : |
Inglés |
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Notas : |
Article history: Article first published online May 19, 2022; Published online September 2022. -- Corresponding Author: Franklin Riet-Correa, Postgraduate Program in Animal Science in the Tropics, School of Veterinary Medicine and Animal Science, Federal University of Bahia, Salvador, Bahia 40170-110, Brazil. Email: franklinrietcorrea@gmail.com -- This work was funded by National Institute of Agricultural Research (INIA) of Uruguay (Project CL 44), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil, (Finance Code 001) and National University of La Plata (Project V270). A postgraduate scholarship was provided to Mizael Machado by INIA, Uruguay. |
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Contenido : |
ABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It is proposed that the two different VSMC-S phenotypes in calcinosis are due to the expression of at least two genetically different types of these cells induced by the action of 1,25(OH)2D3. © The Author(s) 2022. MenosABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It ... Presentar Todo |
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Palabras claves : |
Arterial mineralization; Arteries; Enzootic calcinosis; Exosomes; Pathogenesis; PLATAFORMA DE SALUD ANIMAL; Toxicity; Vascular smooth muscle cells. |
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Asunto categoría : |
L50 Fisiología y bioquímica animal |
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Marc : |
LEADER 03391nam a2200313 a 4500
001 1063233
005 2022-11-30
008 2022 bl uuuu u01u1 u #d
022 $a0300-9858
024 7 $a10.1177/03009858221098430$2DOI
100 1 $aMACHADO, M.
245 $aPoisoning by Nierembergia veitchii$bEffects on vascular smooth muscle cells in the pathogenesis of enzootic calcinosis.$h[electronic resource]
260 $aVeterinary Pathology, 2022, Volume 59, Issue 5, pages 814-823. doi: https://doi.org/10.1177/03009858221098430$c1177
500 $aArticle history: Article first published online May 19, 2022; Published online September 2022. -- Corresponding Author: Franklin Riet-Correa, Postgraduate Program in Animal Science in the Tropics, School of Veterinary Medicine and Animal Science, Federal University of Bahia, Salvador, Bahia 40170-110, Brazil. Email: franklinrietcorrea@gmail.com -- This work was funded by National Institute of Agricultural Research (INIA) of Uruguay (Project CL 44), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil, (Finance Code 001) and National University of La Plata (Project V270). A postgraduate scholarship was provided to Mizael Machado by INIA, Uruguay.
520 $aABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It is proposed that the two different VSMC-S phenotypes in calcinosis are due to the expression of at least two genetically different types of these cells induced by the action of 1,25(OH)2D3. © The Author(s) 2022.
653 $aArterial mineralization
653 $aArteries
653 $aEnzootic calcinosis
653 $aExosomes
653 $aPathogenesis
653 $aPLATAFORMA DE SALUD ANIMAL
653 $aToxicity
653 $aVascular smooth muscle cells
700 1 $aCASTRO, M.B.
700 1 $aWILSON, T. M.
700 1 $aGONÇALVES , A. A. B.
700 1 $aPORTIANSKY, E.
700 1 $aRIET-CORREA, F.
700 1 $aBARROS, S. S.
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| 81. |  | ROMAN, L.; BANCHERO, G.; MORALES-PIÑEYRUA, J.; ACOSTA, Y.; MENDOZA, A.; PLA, M.; LA MANNA, A. Acceso a sombra durante el periodo seco de vacas lecheras: 1. Peso, condición corporal y eficiencia placentaria.[Effect of access to shade during the dry period in dairy cow: 1. Body weight, condition score and placental efficiency]. SP 76. In: Congreso Argentino de Producción Animal, 37., 2014. Resúmenes. Joint; Meeting American Society of Animal Science, 2nd.; Congreso Sociedad Chilena de Producción , 39. Buenos Aires 20-22 de octubre. AR: ASAS/AAPA, 2014. p.288. (Revista Argentina de Producción Animal; 2014; 34; supl.1).| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA La Estanzuela. |
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| 82. | | ROMAN, L.; BANCHERO, G.; MORALES-PIÑEYRUA, J.; ACOSTA, Y.; MENDOZA, A.; PLA, M.; LA MANNA, A. Efecto del acceso a sombra artificial durante el periodo seco de vacas lecheras.[Effect of access to artificial shade during the dry period in dairy cows]. SP 52. In: Congreso Argentino de Producción Animal, 38., 2015. Resúmenes. Santa Rosa, La Pampa, AR: ASAS/AAPA, 2015. p. 134. (Revista Argentina de Producción Animal; 2015; 35; supl.1).| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA La Estanzuela. |
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| 83. | | ROMAN, L.; BANCHERO, G.; MORALES-PIÑEYRUA, J.; ACOSTA, Y.; MENDOZA, A.; PLA, M.; RAGGIO, V.; MEDINA, G.; WALLER, A.; LA MANNA, A. Efecto del acceso a sombra artificial durante el período seco en vacas lecheras Holando. In: Día de Campo Manejo de Estrés Térmico en Ganado Lechero. La Estanzuela: INIA, 2014. p. 19-22. (Serie Actividades de Difusión; 728).| Biblioteca(s): INIA La Estanzuela. |
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| 84. | | ROMAN, L.; LA MANNA, A.; ACOSTA, Y.; MENDOZA, A.; AGUILAR, I.; MORALES-PIÑEYRUA, J.; PLA, M.; LAURA ASTIGARRAGA, L.; SARAVIA, C. Evaluación de medidas de mitigación del estrés por calor sobre las respuestas productivas de vacas lecheras de alta producción. In: Día de Campo: producción de forraje y leche en verano. La Estanzuela, Colonia, (Uruguay): INIA, 2013. p. 15. (Serie Actividades de Difusión; 705).| Biblioteca(s): INIA La Estanzuela. |
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| 85. | | ROMAN, L.; LA MANNA, A.; BANCHERO, G.; MORALES-PIÑEYRUA, J.; ACOSTA, Y.; MENDOZA, A. Vacas secas: una categoría a no descuidar en veano. La Lechera, v. 4, n. 12, p. 62-64, 2015.| Tipo: Artículos en Revistas Agropecuarias |
| Biblioteca(s): INIA La Estanzuela. |
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| 86. | | ROMAN, L.; SARAVIA, C.; ASTIGARRAGA, L.; BENTANCUR, O.; ACOSTA, Y.; PLA, M.; MENDOZA, A.; MORALES-PIÑEYRUA, J.; LA MANNA, A. El acceso a sombra asociado o no con aspersión y ventilación mejora las variables fisiológicas y el desempeño productivo de vacas holando en el suroeste de Uruguay. In: Día de Campo Manejo de Estrés Térmico en Ganado Lechero. La Estanzuela: INIA, 2014. p. 13-16. (Serie Actividades de Difusión; 728).| Biblioteca(s): INIA La Estanzuela. |
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| 87. | | VENTURINI, G.C.; BALDI, F.; ERNANDES, M.; REZENDE, R.G.; PEREIRA, A.S.C.; BANCHERO, G.; BRITO, G.; LA MANNA, A.; FERNANDEZ, E.; ACOSTA, Y.; FORMOSO, F.; MONTOSSI, F. Effect of sorghum grain silage and roughage management on animal performance and meat and carcass traits in steers finished in feedlot. In: International Congress of Meat Science and Technology (ICoMST), 59, 2013, Izmir, Turquía.[Resumen expandido]| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA La Estanzuela. |
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| Registros recuperados : 87 | |
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